This present study examined the potential predictive value of NAT10 for AS and data showed that the AUC for distinguishing new-onset AS from HC was up to 0.702 (a sensitivity of 48.21%, and a specificity of 90.38%) and the AUC for distinguishing new-onset AS from RA + SLE was up to 0.723 (a sensitivity of 67.86%, and a specificity of 75.00%). The gene discussed is NAT10; the disease is systemic lupus erythematosus.