According to the Canadian Rheumatology Association Recommendations for the Assessment and Monitoring of Systemic Lupus Erythematosus, anti-Ro/SSA and/or anti-La/SSB should be detected before pregnancy and during the first 3 months of pregnancy for women with SLE to monitor and implement prophylaxis treatment in a timely manner, mitigating the risk of gestating a fetus with ACHB and improving prognosis [44]. The gene discussed is CALR; the disease is systemic lupus erythematosus.