The 2020 American College of Rheumatology Reproductive Health Management Guidelines for Rheumatoid and Musculoskeletal Diseases conditionally recommend hydroxychloroquine (HCQ) treatment for all pregnant women with positive anti-Ro/SSA and/or anti-La/SSB antibodies to minimize the risk of ACHB [34]. The gene discussed is TRIM21; the disease is musculoskeletal system disorder.