PPARA and obesity due to melanocortin 4 receptor deficiency: For example, CDK5 is a strong candidate for BMI: CDK5 encodes cyclin-dependent kinase 5 (Cdk5) that has diverse functions [50] in neurons, adipocytes and beta cells; Cdk5 affects obesity and diabetes through phosphorylation of PPAR\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\gamma$$\end{document}γ [51]; and a mutation in CDK5 causes lissencephaly with multiple neurodevelopmental features [52].