Apart from the well-known obesity genes [42] (LEP, PCSK1, NTRK2), we identified several BMI effector genes that have not been reported in GWAS [40, 46] but are supported by multiple converging lines of evidence (Additional file 2: Figs. S10-S12). The gene discussed is PCSK1; the disease is obesity due to melanocortin 4 receptor deficiency.