No causal relationship was found between the five plasma lipids (low-density lipoprotein (LDL)-cholesterol, high-density lipoprotein (HDL)-cholesterol, total cholesterol, apolipoprotein A1, and apolipoprotein B) and FGID (including IBS and FD) (Tables 2, 3). The gene discussed is APOA1; the disease is Fabry disease.