This axis may also contribute to colon cancer progression and metastasis by inducing IFITM3 expression (directly by inhibition of IFITM3 transcription or indirectly by activating the Wnt/β-catenin pathway) and regulating EMT in CRC by targeting Snail and E-cadherin53,57. This evidence concerns the gene SNAI1 and malignant colon neoplasm.