CD68 and hepatocellular carcinoma: The Wnt/β-catenin pathway is important for monocyte-to-macrophage differentiation and macrophages M2 polarization. Yang et al. found that there is abundant nuclear β-catenin accumulation in M2 CD68 + macrophages from human HCC biopsies, and decreasing the level of β-catenin in M2 macrophages could inhibit HCC growth [57].