MAPK8 and cardiovascular disorder: It is well-known that TAX1BP1 plays an important role in the regulation of various physiological and pathological phenomena, such as cell apoptosis, embryonic development and immunity through NF-kB and JNK signaling pathways, but it is also widely observed that abnormal expression of this protein is related to inflammation, malignant tumors, circulatory system diseases, etc. [43–45].