Also, eight targets of hsv1-miR-H1-5p, as the downregulated HSV1 miR in GBM tissues, are among the significantly upregulated genes in GBM tissues; these genes are MELK, FZD2, IL1RN, NOVA1, MYH10, TMEM97, PTPRZ1, and PDGFC (Fig. 2D, and Table 1). The gene discussed is IL1RN; the disease is glioblastoma.