Also, hsv1-miR-H1-5p, as a downregulated HSV1 miR in GBM tissues, can target the expression of MELK, FZD2, NOVA1, TMEM97, PTPRZ1, and PDGFC in non-tumoral brain tissues and these genes are expressed in astrocytes. This evidence concerns the gene FZD2 and glioblastoma.