KIT and gastrointestinal stromal tumor: Additional profiling procedures were conducted on patient-derived or CRISPR/Cas9-generated isogenic GIST cell line models for PDGFRA (T1-a-D842V, T1-a-G680R, and T1-a-T674I/R) and KIT (GIST-T1, T1-D816E, T1-T670I) as well as GIST-48B (Fig. 3, Table 1, Supplementary Tables 1 and  12).