The p53-mediated apoptosis of immune cells, the regulation of the LIF/IL12/MHC-II axis to inhibit T cell activation, and the protecting effect of LIF on ISC are important underlying mechanisms by which p53 protects against radiation-induced GI syndrome, which has potential translational applications to protect against radiation-induced GI syndrome. This evidence concerns the gene LIF and radiation-induced gastrointestinal mucositis.