After further screening by LASSO, 9 genes (DDX60, EIF2AK2, IRF9, IFITM3, STAT1, IFI6, IFNGR1, ISG15, SOCS3) were selected and presented to 11 machine learning algorithms to validate their value for SLE. Here, EIF2AK2 is linked to systemic lupus erythematosus.