IRF9 and systemic lupus erythematosus: After LASSO further selection of hub genes, 9 genes (DDX60, EIF2AK2, IRF9, IFITM3, STAT1, IFI6, IFNGR1, ISG15, SOCS3, Fig. 2B–C) were used to construct models for identifying SLE through 11 machine learning algorithms.