After further screening by LASSO, 9 genes (DDX60, EIF2AK2, IRF9, IFITM3, STAT1, IFI6, IFNGR1, ISG15, SOCS3) were selected and presented to 11 machine learning algorithms to validate their value for SLE. The gene discussed is IFITM3; the disease is systemic lupus erythematosus.