Therefore, these results strongly support an important role for mutp53-CIN in inducing tumor cell-intrinsic resistance to anticancer immunity through NC-NF-κB-mediated inhibition of IFN signaling or IFN tachyphylaxis—a process of reduction in IFN responsiveness to repetitive stimulation—which was recently shown by Bakhoum and colleagues to play an important role in CIN-induced immune suppression and metastasis65. Here, PDXP is linked to cervical squamous intraepithelial neoplasia.