Moreover, since canonical NF-κB activation requires stimulation by extracellular ligands, whereas NC-NF-κB signaling can be activated by CIN16,52, our finding of GOF mutp53-MCM5-CIN-cGAS-STING-NC-NF-κB signaling not only demonstrates a novel GOF mechanism of mutp53 but also strongly suggests that NC-NF-κB activation is a common mechanism involved in all inactivating p53 mutations that lead to CIN. Here, PDXP is linked to cervical squamous intraepithelial neoplasia.