Here, in addition to supporting that CIN induces NC-NF-κB signaling16,52, our results showed that mutp53-MCM5-CIN-cGAS-STING-induced NC-NF-κB signaling not only promotes metastasis but also has an inhibitory role in IFN signaling. This evidence concerns the gene MCM5 and cervical squamous intraepithelial neoplasia.