The work presented here confirms these other investigators’ findings, highlights the importance of CIN in p53 mutation-induced oncogenic phenotypes, and further demonstrates that there is indeed a causal relationship between mutp53 GOF and CIN, in which mutp53 actively predisposes cells to replication stress and CIN through interaction with MCMs and consequent deregulation of the MCM2-7 complex. This evidence concerns the gene PDXP and cervical squamous intraepithelial neoplasia.