Together, these results showed that IFN-low/Inf-high tumors are associated with an immunosuppressive tumor microenvironment, strongly suggesting that mutp53-MCMs-CIN-cytosolic DNA-STING-induced NC-NF-κB signaling, through inhibition of IFN and activation of inflammation-related signaling in tumor cells, has an important role in tumor progression and the resistance to anti-tumor immunity of tumors with TP53 mutations (Fig. 6k). The gene discussed is TP53; the disease is neoplasm.