Our results also showed that compared with the control, expression of murine R270H mutp53 in mouse breast cancer 4T1 cells exhibited GOF activity to promote tumor growth when cells were injected into the mammary fat pads of syngeneic BALB/c mice, but this GOF activity was abolished by further knockdown of RelB expression (Fig. 5a). The gene discussed is RELB; the disease is breast carcinoma.