In summary, our work reveals a tumor cell-intrinsic mechanism of mutp53 GOF involving mutp53-MCMs-induced CIN, leading to the activation of cytosolic DNA-cGAS-STING-NC-NF-κB signaling, which plays an important role in promoting metastasis and immunosuppression (Fig. 6k). The gene discussed is NFKB1; the disease is neoplasm.