In contrast, when the same group of 4T1 stable cells was orthotopically injected into immunodeficient SCID mice, all tumors grew faster than in immunocompetent BALB/c mice (Fig. 5b vs. 5a), but no mutp53 GOF activity was observed; neither expression of R270H mutp53 nor further knockdown of RelB had an impact on tumor growth when compared with the control in SCID mice (Fig. 5b). Here, RELB is linked to neoplasm.