Although LOF mutations of p53 impair cell cycle checkpoints and DNA repair, which can lead to the development of CIN2–4, accumulating evidence has also shown that many mutp53s not only lose the genome-guardian role of wtp53 but also gain oncogenic functions to promote CIN through targeting various proteins involved in genome stabilization26. This evidence concerns the gene TP53 and cervical squamous intraepithelial neoplasia.