Although the current study did not directly reveal the role of NLRP12 in PCOS, a study in PCOS mice model mentioned hyperandrogen stimulates chronic low-grade inflammation in the ovary to activate the NLRP3 (another member of the NLR family) inflammasome, further inducing a series of pathologies including ovarian GC pyroptotic death, follicular dysfunction and ovarian interstitial cell fibrosis. This evidence concerns the gene NLRP12 and polycystic ovary syndrome.