To prove that GCA magnifies inflammation in adipocytes via PHB2, adipocyte-specific Phb2 knockdown mice (designated as Phb2-CKD mice) and control mice were generated by injecting with adeno-associated virus serotype 9, which carries aP2 promoter-driven small hairpin RNAs targeting Phb2 (AAV9-shPhb2) or negative control (AAV9-shNC) with a Green fluorescent protein (GFP) reporter gene. Here, PHB2 is linked to chronic kidney disease.