TNF and Insulin resistance: As inflammation-associated factors and HOMA-IR were also elevated in individuals with obesity15, we analyzed the correlation between GCA and HOMA-IR, serum IL6,TNFα and MMP2, and found that GCA expression levels displayed a positive correlation with HOMA-IR, IL6 TNFa and MMP2 (Fig. 1h–k), further implicating a role of GCA with insulin resistance and metainflammation in human.