By broadening the range of variants of genes, including MYO15A linked to hereditary hearing loss(HL), and employing highly precise sensitive methodologies, such as NGS-based NIPT [29], NGS-based pre-implantation genetic testing (PGT-A, PGT-M) [30], it would effectively avoid the occurrence of children with ARNSHL through pregnant women screening or routine-based embryo screening. Here, MYO15A is linked to Hodgkins lymphoma.