OTUB2 and neoplasm: When wild-type (WT, Control) and OTUB2-knockout (KO) MC38 cells were inoculated parallel into syngeneic and immunodeficient mice, knocking out OTUB2 reduced MC38 tumor growth in immunocompetent C57BL/6J mice but not in immunodeficient BALB/c-nude mice (Fig. 1e, f).