Inspired by the previously observed association among elevated OTUB2 mRNA levels, worse overall or disease-free survival, and reduced CD8+ T-cell infiltration (estimated from a CD8+ T-cell signature) in a pancancer analysis of 32 human tumor datasets from the TCGA, we further investigated the clinical relevance of OTUB2 protein expression in cohorts of lung squamous cell carcinoma (LUSC) patients and lung adenocarcinoma (LUAD) patients. This evidence concerns the gene CD8A and squamous cell lung carcinoma.