Interestingly, we found that Ikke-/-Tbk1-/-Ripk1wt/D138N and IkkeK38A/K38ATbk1D135N/D135NRipk1wt/D138N, but not Tbk1-/-Ripk1wt/D138N or Tbk1D135N/D135N Ripk1wt/D138N mice, displayed alopecia before weaning with hair growth recovering almost completely by the age of 8 weeks (Fig. 1f, g). The gene discussed is IKBKE; the disease is alopecia.