IL18R1 and Splenomegaly: Indeed, combined deficiency of IL-1R1, IL-18R1, and IL-33R strongly suppressed splenomegaly and myeloid cell expansion induced by myeloid cell specific inhibition of TBK1 and IKKε, providing evidence that RIPK1-mediated cell death resulting in IL-1 family cytokine production by myeloid cells contributes to the pathology.