To investigate whether the granulocytosis and monocytosis observed in IkkeK38A/K38ATbk1D135N/D135NRipk1wt/D138N mice were caused by loss of myeloid cell-intrinsic function of TBK1 and IKKε, we generated IkkeK38A/K38ATbk1fl/D135NCx3cr1-Crewt/tg mice, which lack TBK1 kinase activity in myeloid cells and IKKε kinase activity in all cells (Fig. 3a). Here, IKBKE is linked to Increased total granulocyte count.