IkkeK38A/K38ATbk1fl/D135NK14-Crewt/tg mice did not develop alopecia (Fig. 1f, g), showing that combined inhibition of IKKε and TBK1 kinase activity caused RIPK1 kinase-dependent transient hair loss by a non-keratinocyte-intrinsic mechanism. The gene discussed is IKBKE; the disease is alopecia.