CD16-CD103+ TI-NK cells shared with CD16+ TI-NK cells the expression of transcripts for EOMES and inhibitory KIR yet showing a tissue-resident profile featured by the highest expression of the transcription factor HOBIT (ZNF683) and tissue/tumor retention molecules such as CD9 and CD151 (in addition to CD103), reminiscent of TGFβ-induced ILC1 and akin to tissue-resident memory T cells [24] (Fig. 5B). This evidence concerns the gene ZNF683 and neoplasm.