EP300 and Alzheimer disease: We observed a slight but significant overlap between genes downregulated in either EP300 or CBP KD in APPDup neurons and genes upregulated in Old brain compared to AD brains (Jaccard index = 120/3718 genes, p = 2.61e-08), but no significant overlap between EP300/CBP KD-downregulated genes and AD-upregulated genes (Jaccard index = 64/3718, p = 0.613) (Fig. 5E).