Though AD pathway genes are not significantly enriched in APPDup neurons relative to NDC neurons (Additional file 2: S6A), a significant overlap exists between the set of genes upregulated in APPDup relative to NDC neurons and the sets of genes downregulated in HAT knockdown conditions in APPDup neurons (Additional file 2: Fig. S6B), suggesting the involvement of H3K27ac HAT enzymes in transcriptional changes brought about by APP duplication. The gene discussed is APP; the disease is Alzheimer disease.