Finally, KEGG pathway analysis revealed that the majority of the AD-related DEGs in both EP300 (Additional file 2: Fig. S7) and CBP KD (Additional file 2: Fig. S8) in APPDup neurons are downregulated (blue), supporting the view that EP300 and CBP positively regulate the expression of AD-related genes. The gene discussed is CREBBP; the disease is Alzheimer disease.