Gene Set Enrichment Analysis (GSEA) revealed that genes downregulated in EP300 and CBP KD (i.e. CBP- and EP300-regulated in our system) were more highly expressed in Old brains in both APPDup (Fig. 5A, B) and NDC (Fig. 5C, D) neurons; we note that a fraction of significant EP300- and CBP-positively regulated genes were highly expressed in AD patients (Fig. 5A–D). Here, CREBBP is linked to Alzheimer disease.