We found that the genes downregulated in CBP/EP300 KD in both APPDup (Fig. 5F, blue) and NDC neurons (Additional file 2: Fig. S11A, blue bars) were significantly associated with altered H3K27ac enrichment in either AD patient or Old brains; these were compared to upregulated genes (Fig. 5F, Additional file 2: Fig. S11A, red bars) or background genes unaffected by CBP/EP300 KD (grey bars). The gene discussed is EP300; the disease is Alzheimer disease.