However, in our iPSC-neurons, EP300 or CBP knockdown reduced total H3K27ac abundance (Fig. 3D, E), which correlated with widespread downregulation of gene transcription in both APPDup and NDC neurons (Fig. 4A, B, Additional file 2: Fig. S5A, B), including important genes in Alzheimer’s disease pathways (Fig. 4F, G, Additional file 2: Fig. S5F, G, Additional file 2: Fig S6, Additional file 2: Fig. S7). This evidence concerns the gene EP300 and early-onset autosomal dominant Alzheimer disease.