We observed the same pattern in NDC neurons, where EP300/CBP KD-downregulated genes overlapped significantly with Old-upregulated genes (Jaccard index = 80/2226, p = 6.65e-06) but not with AD-upregulated genes (Jaccard index = 40/2142, p = 0.75) (Additional file 2: Fig. S10A). Here, EP300 is linked to Alzheimer disease.