Such pathways included lipopolysaccharides (LPS)/interleukin 1 (IL-1)-mediated inhibition of retinoid X receptor (RXR), hepatic fibrosis/HSC activation, liver X receptor (LXR)/RXR activation, and fatty acid β-oxidation I. Molecules of interest in the IPA pathway are included in Additional file 1: Table S1. The gene discussed is IL1B; the disease is Hepatic fibrosis.