PNPLA3 and metabolic dysfunction-associated steatotic liver disease: The downregulation of Patatin-like phospholipase domain-containing protein 3 (Pnpla3) in KO mice is consistent with human research, where genetic variants of PNPLA3 have been linked to non-alcoholic steatohepatitis (NASH) and NAFLD [51], and higher liver TAG content [52].