These results suggest that PLCG2, BCL6, IGF2BP2, FMN1, MGLL, APP, CENPN, SNRPN, ZDHHC19, NTSR1, ALPK1, VAV2, SATB1, and FCHO1 may represent novel genes involved in the potential pathogenesis of sepsis and potential therapeutic targets. Here, CENPN is linked to Sepsis.