Single-cell analysis revealed increased expression of PLCG2 in immune cells of sepsis compared to healthy individuals, increased expression of BCL6 in sepsis Pre-B cell CD34−, increased expression of IGF2BP2 in GMP, increased expression of FMN1 in sepsis Pre-B cell CD34− and Monocytes, increased expression of MGLL in sepsis Platelets, and increased expression of APP and CENPN in sepsis Pre-B cell CD34−. This evidence concerns the gene CENPN and Sepsis.