TMC1 and hearing loss disorder: Previously, we have generated iPSCs from a patient carrying TMC1 p.M418K mutation (M+/−) [18] and a gene-corrected iPSC line (M+/C) using CRISPR/Cas9 [19], as well as a normal control iPSCs (M+/+) from the patient’s normal son, who has no TMC1 mutation and hearing loss.