In conclusion, these data suggest that lncRNA FOXD1-AS1 may serve as a valuable predictor for assessing the efficacy of 5-FU in personalized therapy for PC This promising finding highlights the need for further research in PC and other malignancies where the lncRNA FOXD1-AS1 is known to play a functionally relevant role. Here, FOXD1 is linked to pachyonychia congenita.