BRCA1 and cancer: However, multivariate logistic regression demonstrated that having family members with cancer (OR = 2.36, 95% CI = 1.00–5.54), bilateral cancer (OR = 4.78, 95% CI = 1.61–14.20), HER2-(OR = 8.23, 95% CI = 3.25–20.84), Ki67 ≥ 15% (OR = 3.88, 95% CI = 1.41–10.65) were associated with BRCA1/2 mutation (Fig. 3B).