It can bind to the phosphatase PP-1α and facilitate its nuclear aggregation [22], as well as regulate the selective polyadenylation of ZBTB4 playing a vital role in regulating glucose and lipid metabolism, and the proliferation of GBM cells [23]; SNORA63, a member of the H/ACA box snoRNAs family, is located on chromosome 3 and is also known as U107 small-nucleus RNA and small-nucleus E3, but no comprehensive literature focuses on its expression and function; SNORD14E is a member of the C/D box snoRNAs family. This evidence concerns the gene ZBTB4 and glioblastoma.