Therefore, this study aims to investigate the interest in genetic risk disclosure for dementia within the context of research participation and how this relates to (i) participant characteristics and (ii) different hypothetical risk scenarios corresponding to the APOE genotypes and (iii) the expected impact of risk disclosure among cognitively normal individuals of the Dutch Brain Research Registry (in Dutch: Hersenonderzoek.nl) [31]. This evidence concerns the gene APOE and dementia.