Liu et al. explored IL-24 and TRAIL expressed by Ad-AFP-D55-IL-24 and Ad-AFP-D55-TRAIL,which induced apoptosis through Caspase-8 and Caspase-9 signaling pathways, inhibited HCC cell growth, and this combination increased animal survival by inhibiting tumor growth in Huh-7 cell xenograft mice, showing a strong antitumor effect in vivo [95]. The gene discussed is AFP; the disease is hepatocellular carcinoma.