In 1985, HAC was first described in a case of gastric adenocarcinoma by Ishikura et al. [2] Like the typical HCC, immunohistochemical (IHC) staining of HAC usually showed positive AFP stains (91.6%), together with elevated serum levels of AFP in most cases but not in all [1, 3]. This evidence concerns the gene AFP and hepatocellular carcinoma.