Those genes were incorporated into a LASSO regression model to select the prognostic signature for CRC, resulting in six genes (NUMBL, TSPAN11, PHF21A, PDGFRA, ZNF385A, and RIMKLB) were finally identified for the LymScore and immune cell infiltration-related risk model construction (Fig. 3B-C). This evidence concerns the gene ZNF385A and colorectal carcinoma.