Vascular endothelial growth factor C (VEGF-C), interleukin-4 (IL-4), colony-stimulating factor 2 (CSF2), prospero homeobox 1 (PROX1), and TEK receptor Tyrosine Kinase (TEK) is significantly associated with lymph node metastasis in renal cell carcinoma (RCC) [27, 28]. The gene discussed is PROX1; the disease is metastatic malignant neoplasm in the lymph nodes.