Meanwhile, downregulation of PPP3CC has been linked with an autophage-related prognostic signature for hepatocellular carcinoma, and suppression of PPP3CC by ZEB1 activates NF-kB signaling, leading to glioma cell proliferation and invasion [35], indicating that PPP3CC acts as a tumor suppressor in these cancers. This evidence concerns the gene NFKB1 and cancer.