CD4 and neoplasm: Subtype 1 (innate immunity) showed an enrichment of innate immune cells, an exclusion of activated CD4+ T cells, CD8+ T cells and B cells, and high expression of tumor-promoting factors such as TGF-β; subtype 2 (T cell dominant) exhibited enrichment of TILs; while subtype 3 (tumor dominant) showed a paucity of TILs [70].