Indeed, recent evidence from randomized controlled trials demonstrated that periodontal treatment reduces systemic levels of interleukin (IL)-6, C-reactive protein, BP, total cholesterol, and E-selectin [12, 24], improves endothelial function [12], and improve metabolic helps glycaemic control and kidney function in patients with type 2 diabetes [25]. Here, CRP is linked to type 2 diabetes mellitus.