Furthermore, by using four glioma cell lines (U251, T98G, LN-229, and A172), it has been shown that the interplay between NQO1 and the anti-oncogenic miR-1321 with the oncogene serpin family A member 1 has been shown to impact the proliferation and apoptosis of glioma cells [265]. This evidence concerns the gene SERPINA1 and central nervous system cancer.