In postmortem brain and lumbar spinal cord tissues obtained from 5 patients with ALS, a reduction in both Nrf2 mRNA and protein expression levels has been observed in neurons within the motor cortex and spinal cord compared to autoptic specimens from 5 individuals without any neurological or psychiatric disease, suggesting an impaired capacity of these cells to counteract oxidative stress. Here, NFE2L2 is linked to amyotrophic lateral sclerosis.