These experimental and clinical assessments indicate that NQO1 may be implicated in the pathophysiology of a wide range of both acute and chronic neurological disorders, including epilepsy, AD, PD, amyotrophic lateral sclerosis (ALS), MS, cerebrovascular diseases, and brain malignant tumors (Table 1) (Fig. 4) [115]. This evidence concerns the gene NQO1 and Alzheimer disease.