Investigations conducted on human glioblastoma (GBM) involving ten patients, as well as primary brain tissue cell cultures and human neuroblastoma (SH-SY5Y) cells, have revealed that the regulation of the Nrf2 pathway and the expression of downstream antioxidant enzymes, such as NQO1, HO-1, and GST, are crucial in the regulation of ROS activity, detoxification of xenobiotics, and inhibition of brain cancer progression [50, 249, 250]. Here, NFE2L2 is linked to neuroblastoma.