RHO and lung adenocarcinoma: Patients with high expression of RACGAP1 in lung adenocarcinoma have a poorer prognosis, and Rac gTPase-activating protein 1 (RACGAP1) is a component of the central spindle complex, which acts as a microtubule-dependent and Rho-mediated signaling cytoplasmic divisions during the formation of myosin contractile rings [19].