It has been shown that RACGAP1 is overexpressed in a variety of cancers including breast [20], esophageal [21], gastric [22], hepatocellular carcinoma (HCC) [23], and ovarian [24], and that the high expression of RACGAP1 correlates with tumor aggressiveness and poor prognosis, which is in agreement with the present findings. This evidence concerns the gene RACGAP1 and hepatocellular carcinoma.