RACGAP1 and cancer: It has been shown that RACGAP1 is overexpressed in a variety of cancers including breast [20], esophageal [21], gastric [22], hepatocellular carcinoma (HCC) [23], and ovarian [24], and that the high expression of RACGAP1 correlates with tumor aggressiveness and poor prognosis, which is in agreement with the present findings.