Overexpression of CTGF has been found in various cancers, including pancreatic cancer, prostate cancers, and gliomas, acute lymphoblastic leukemias, esophageal squamous cell carcinomas [13–17], and is implicated in tumor progression by regulating proliferation, migration, invasion, and epithelial–mesenchymal transition (EMT) of cancer cells [18]. Here, CCN2 is linked to neoplasm.