In this study, AdipoRon was orally administered to STZ-induced diabetic mice, and relevant experimental data revealed that AdipoRon alleviated oxidative stress and apoptosis of the retina by activating the AdipoR1/AMPK/ACC pathway, improved retinal function, and reversed retinal damage caused by long-term hyperglycemia and hyperlipemia. Here, ADIPOR1 is linked to familial hyperlipidemia.