High cholesterol intake, an important hallmark of Western diet, can result in hypercholesterolemia, wherein excessive cholesterol, especially LDL-C, accumulates into macrophages and drives inflammatory response through various mechanisms, which include amplifying Toll-like receptor (TLR) signaling [63], activating NOD-, LRR- and pyrin domain-containing 3 (NLRP3) inflammasome [64], and stimulating the proliferation and maturation of monocytes and neutrophils in the bone marrow and spleen [65], thereby fueling the development of atherosclerotic CVD (ASCVD), including stroke. This evidence concerns the gene NLRP3 and atherosclerosis.