By using the TIMER2.0 program, we found that AIM2 mRNA levels positively correlate with the infiltration levels of IFNγ-producing CD8 + T cells and nature killer (NK) cells and TNFα-secreting M1 macrophages in TCGA HNSCC samples (Fig. 3D). The gene discussed is AIM2; the disease is head and neck squamous cell carcinoma.