CD4 and Dravet syndrome: In conclusion, we provide innovative data on the role of SNX27 in T lymphocytes and demonstrate that the phenotype observed in CD4-Cre-SNX27fl/+ mice shows striking similarities not only to that observed in individuals with DS, but also in aging regarding the naïve T cell pool in steady-state as well as decreased IL-2 secretion, which contrasts with enhanced mRNA expression of well-characterized inflammatory cytokines and lytic enzymes.