TREX1 and systemic lupus erythematosus: Mutations in TREX1 are associated with the development of several autoimmune diseases, including Aicardi-Goutières Syndrome (AGS) [18], systemic lupus erythematosus (SLE) [19], familial chilblain lupus (FCL) [20], and retinal vasculopathy with cerebral leukodystrophy (RVCL) [21].