Using transfection of KD-MTTP lentivirus into the abdominal fat of obese mice, a mechanistic study in colorectal cancer organoids found that adipocyte-derived exosomes could reduce the level of PUFA by upregulating GPX4 and xCT through the MTTP/PRAP1/ZEB1 axis, thereby inhibiting the production of lipid ROS and the incidence of ferroptosis [123]. The gene discussed is MT-TP; the disease is colorectal cancer.