By establishing relevant cell models, such as primary stromal cells and cancer cells, they found that cancer-associated fibroblast (CAF)-derived exosomes can secrete miR-552, a potential inhibitor of ALOX15, and hnRNPA1 as well as USP7 can increase the secretion and expression of miR-552 in exosomes. This evidence concerns the gene HNRNPA1 and cancer.