The second cluster of DEGs, including FGFR2, KDR2 and MET, indicates the importance of key cancer-related pathways, including the PI3K-Akt signaling pathway, EGFR tyrosine kinase inhibitor resistance pathway, Rap1 signaling pathway, Ras signaling pathway, and MAPK signaling pathway. The gene discussed is EGFR; the disease is cancer.