High neutrophil levels in tissues secrete numerous inflammatory mediators like vascular endothelial growth factor (VEGF), tumor necrosis factor-a (TNF-a), interleukin-2 (IL-2), interleukin-10 (IL-10), and interleukin-6 (IL-6) which creates a suitable environment for cancer progression [25–27]. The gene discussed is TNF; the disease is cancer.