TCF7L2 and gestational diabetes: The underlying mechanism of action of TCF7L2 and CAPN10 in the pathogenesis of GDM remains unclear [52], although TCF7L2 and CAPN10 may directly affect the function of pancreatic islet β-cells [53], resulting in decreased secretion of insulin and glucagon-like peptides, and subsequently leading to increased production of endogenous glucose [54].