We found consistent, positive associations of CCBs with BD and SCZ while null association with MDD using weighted median and weighted mode methods, after removing SNPs related to CACNA1C gene in the Europeans and CACNAB2 gene in the East Asian population (Additional file 1: Fig. S2), after removing SNPs related to BMI (Additional file 1: Fig. S3), and after removing SNPs related to cause of death for the European population (Additional file 1: Fig. S4). The gene discussed is CACNA1C; the disease is Behcet disease.