In the gene-specific analysis for CCBs, CACNA1C (based on two SNPs) was associated with a higher risk of BD (OR per 5 mmHg reduction in SBP 2.54, 95% CI 1.75 to 3.68) and SCZ (OR per 5 mmHg reduction in SBP 2.88, 95% CI 2.01 to 4.13) in the European population, while CACNAB2 (based on seven SNPs) was associated with a higher risk of SCZ (OR per 5 mmHg reduction in SBP 1.49, 95% CI 1.03 to 2.13) and a lower risk of MDD (OR per 5 mmHg reduction in SBP 0.76, 95% CI 0.6 to 0.97) in East Asians (Additional file 1: Fig. S7). The gene discussed is CACNA1C; the disease is major depressive disorder.