In this investigation, we discovered a significant association between PD-L1 expression and immune cells that were infiltrating OV, BRCA, UCEC, COAD, LGG, KIRC, LIHC, PAAD, SKCM, TGCT, THCA, PRAD, and HNSC, which indicates that PD-L1 may lead to the inhibition of tumor or tumorigenesis by altering the TIL status. This evidence concerns the gene CD274 and neoplasm.