ICOS and neoplasm: CD274 is positively correlated with PDCD1LG2, TNFRSF9, CD80, HAVCR2, CD200R1, ICOS, TIGIT, and CTLA4, while is negatively correlated with BTNL2 and VTCN1 (Fig. 7C) in many tumor types in these immunosuppressive marker genes.