In contrast, tumors have lower levels of CD274 than normal tissues did in COAD (colon adenocarcinoma), KIRC (kidney renal clear cell carcinoma), UCEC (uterine corpus endometrial carcinoma), KIRP (kidney renal papillary cell carcinoma), PAAD (pancreatic adenocarcinoma), LUSC (lung squamous cell carcinoma), LUAD (lung adenocarcinoma), LIHC (liver hepatocellular carcinoma), PRAD (prostate adenocarcinoma), and BRCA (breast invasive carcinoma). The gene discussed is CD274; the disease is colon adenocarcinoma.