Four databases predicted significant negative correlation between miR-622 and FOLR2, and dual luciferase reporter assay verified that miR-622 targeted FOLR2 mRNA 3’UTR and down-regulated FOLR2, a downregulated protein in CRC whose overexpression abolished miR-622 pro-tumor effect and showed countering effect to signature genes in cell cycle process. Here, FOLR2 is linked to colorectal carcinoma.