Analysis of dataset GSE29623, an mRNA and microRNA profile in colon cancer, supported that miR-622 positively correlated with signature genes in cell cycle pathway (Fig. 3I-N), such as CDC6 (r = 0.421), CDK2 (r = 0.336), CCNE1 (r = 0.423), CCNA2 (r = 0.412), CCNA5 (r = 0.350), and MCM10 (r = 0.423). This evidence concerns the gene CCNE1 and malignant colon neoplasm.