Xu et al. reported that siRNA-silenced FOLR2 gene could inhibit the phosphorylation of AKT, mTOR and S6K1 to inhibit cell proliferation and increase apoptosis [28], however this work is limited in vitro and lacking more direct evidence, which still in a way indicated FOLR2 function in tumor cells. The gene discussed is RPS6KB1; the disease is neoplasm.