GPT and neoplasm: As shown in Table 3 and Supplementary Fig. 2, female (adjusted HR = 2.27 [1.30–3.94], p = 0.004), ALT > 68.4 U/L (adjusted HR = 1.88 [1.02–3.45], p = 0.043), DBIL > 93.9 μmol/L (adjusted HR = 4.23 [2.20–8.13], p < 0.001), tumor size > 3.2 cm (adjusted HR = 2.53 [1.40–4.60], p = 0.002), dCCA (adjusted HR = 0.49 [0.28–0.85], p = 0.011), GGT > 600.2 U/L (adjusted HR = 0.53 [0.29–0.97], p = 0.039), SIRLiver/Muscle > 0.7 (adjusted HR = 0.41 [0.20–0.83], p = 0.014), and SIRSpleen/Muscle > 1.9 (adjusted HR = 0.51 [0.29–0.88], p = 0.016) were strongly associated with OS.