VD3 treatment decreased the expression of PINK1 (2.95 ± 0.51 vs 1.72 ± 0.35) and Parkin (2.76 ± 0.19 vs 0.49 ± 0.17) in the lung of high-altitude pulmonary edema rats (Fig. 7D and E). This evidence concerns the gene PINK1 and high altitude pulmonary edema.