However, the differences in the expression of hub genes between the miscarriage group and the non-miscarriage group, and between the hypertensive group and non-hypertensive group were small, except that the expression of PKM was remarkably higher in the hypertensive group than that in the non-hypertensive group (p<0.05) (Fig. 4c, d). The gene discussed is PKM; the disease is spontaneous abortion.